BTCC Reports: Breakthrough List shows Cancer Therapeutics in US Pipeline

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Fight To Live and Break Through Cancer Coalition are communities that fight for change at the Federal Drug Administration (FDA) to transform cancer and terminal disease.  Breakthroughs in science and medicine can change the game in the treatment of serious or life threatening diseases. You and the people you love may encounter such a fight-to-live where you discover your need but inability to access one of those breakthroughs that may be the only option to save your life or to give you a fighting chance.

Break Through Cancer Coalition has identified these compounds for potential “breakthrough” status because they are either or both scientifically and clinically promising to significantly impact cancer care, options and outcomes.

General pharmaceuticals, targeted pharmaceuticals, biologics, and therapeutic vaccines listed herein are investigational drugs yet to be fully proven.  Risk and benefits are not fully established.

Solid tumors    
     
Kidney Cancer    
Dendreon Carbonic Anhydrase IX (CA9)  
  SGN-75  
Celldex CDX-014  
Celldex CDX-1135  
     
Prostate Cancer    
Seattle Genetics MDV3100  
Bristol-Meyers Squibb Ipilimumab®  
Exelixis XL184  
Seattle Genetics / Astellas ASG-5ME  
KuDOS/Astra Zeneca Olaparib (AZD-2281)  
     
Colon, Colorectal Cancer    
Dendreon Carbonic Anhydrase IX (CA9)  
Dendreon Carcinoembryonic Antigen (CEA)  
Genentech Dulanermin (rhApo2L/TRAIL)  
Seattle Genetics SGN-75  
Plexxikon PLX4032  
     
Breast Cancer    
Dendreon Carcinoembryonic Antigen (CEA)  
Genentech PI3 Kinase Inhibitor (GDC-0941)  
Sanofi-Aventis Iniparib  
Exelixis XL184  
Exelixis XL147  
Celldex CDX-011  
Plexxikon PLX3397  
KuDOS/Astra Zeneca Olaparib (AZD-2281)  
 

Lung Cancer

   
GlaxoSmithKline  MAGE-A3  
Dendreon Carcinoembryonic Antigen (CEA)  
Genentech PI3 Kinase Inhibitor (GDC-0941)  
Pfizer Crizotinib  
Avila Therapeutics C01686  
Exelixis XL147  
Exelixis XL765  
Bristol-Meyers Squibb Ipilimumab®  
Boehringer-Ingelhiem BIBF 1120  
     
Bladder Cancer    
Dendreon DN24-02  
Celldex CDX-1307  
     
Cervical Cancer      
Dendreon Carbonic Anhydrase IX (CA9)  
     
Ovarian Cancer    
Exelixis XL184  
Celldex CDX-014  
Boehringer-Ingelhiem BIBF 1120  
KuDOS/Astra Zeneca Olaparib (AZD-2281)  
     
Stomach / Gastro/ Esoph Cancers  
Exelixis XL184  
Micromet MT111  
     
Pancreatic Cancer    
Pharmacyclics PCI-27483  
Seattle Genetics ASG-5ME  
Exelixis XL184  
Threshold Pharma TH-302  
     
Melanoma    
Mannkind MKC1106-MT  
Exelixis XL184  
Amgen Oncovex  
 

Head & Neck Cancers

   
Takeda Millenium Panitimumab (vectibix)  
     
Brain/Glioblastoma    
Celldex CDX 110 –  Rindopepimut  
Pharmacyclics Motexafin Gadolinium  
Exelixis XL184  
Exelixis XL765  
Geron GRN1005  
 

Bone/Sarcoma

   
Ziopharm Palifosfamide  
Pharmacyclics PCI-24781  
     
Thyroid Cancer    
Exelixis XL184  
     
     
Diverse Solid Tumors    
Dendreon D-3263 HCl  
Genentech Akt Inhibitor (GDC-0068)  
Genentech MEK Inhibitor (GDC-0623)  
Genentech Anti-EGFL7 MAb  
Genentech Anti-NRP1 MAb  
Genentech IAP Antagonist (GDC-0917)  
Genentech PI3 Kinase Inhibitor (GDC-0941)  
Genentech Navitoclax (ABT-263)  
Regulus Anti-MiR-34  
Exelixis XL184  
Exelixis XL147  
Exelixis XL765  
Exelixis XL413  
Exelixis XL888  
Celldex CDX-1401  
Micromet MT110  
Micromet BiTE  
Amgen/Biovex Oncovex  
     
     
Hematologic cancers    
     
Leukemia / Lymphoma    
Pharmacyclics PCI-32765  
Pharmacyclics PCI-24781  
Genentech Navitoclax (ABT-263)  
Avila Therapeutics AVL 292  
Micromet MT103  
Seattle Genetics SGN-35  
Seattle Genetics SGN-75  
Seattle Genetics/Genentech SGN-40  
Genentech IAP Antagonist (GDC-0917)  
Genentech PI3 Kinase Inhibitor (GDC-0941)  
Celldex CDX-1127  
Ziopharm Darinasparsin  
     
Multiple Myeloma    
Merck Vorinostat  
Genentech Anti FGFR3 MAb  
Seattle Genetics SGN-40  
Micromet BiTE  
Ziopharm Darinaparsin  
     
Diverse Hematologic Cancers    
Celgene Pomalidomide  
Genentech Anti-CD22 ADC  
Genentech Navitoclax (ABT-263)  
Incyte JAK  
Seattle Genetics SGN-19A